Dr Leila Muresan

Leila’s research interests include artificial intelligence, signal and image processing and computer vision. Her expertise lies in multi-disciplinary research projects with a special focus on microscopy image analysis. Leila is a fellow of the EPSRC College.

[email protected]

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Background

Since her PhD studies, Leila has focused on interdisciplinary research at the frontier of biology, optics and computer science. Following PDRA experiences at IB-ENS, Paris and CGM, Gif-sur-Yvette, she relocated to Cambridge in 2014, joining the Cambridge Advanced Imaging Centre (University of Cambridge).

From September 2023, she is a Senior Lecturer in ARU's School of Computing and Information Science and member of our Biomedical Informatics Research Group.

Leila led several projects in the field of bioimage informatics and is interested in all aspects of research software engineering.

Spoken Languages

• English
• French
• Romanian
• Hungarian (fluent)
• German (basic)

Research interests

• Image analysis applied to microscopy
• Artificial intelligence
• Machine learning
• Deep learning
• Signal and image processing
• Computer vision

Areas of research supervision

• Image analysis
• Artificial intelligence

Teaching

• Introduction to Programming
• Principles of Data Mining and Machine Learning

Qualifications

• PhD in Engineering Sciences, Johannes Kepler University, Linz, Austria: Analysis of single molecule microscopy images with application to ultra-sensitive microarrays
• BSc and MSc in Mathematics and Computer Science, Babeş-Bolyai University, Cluj-Napoca, Romania

Memberships, editorial boards

• Member of the UK Exascale Project Science and Industrial Advisory Board
• Committee Member of the Royal Microscopy Society section for Data Analysis in Imaging
• Member of the Research Software Engineer Society

Research grants, consultancy, knowledge exchange

• 2023: EP/Y008715/1 BioDAC: Bio-image processing at exascale, EPSRC, £447,849, role: PI.
• 2019-2021: Scalable image enhancement for light-sheet microscopy: space varying deconvolution and image fusion, ISSF / Wellcome Trust / Isaac Newton Trust, £85,000, role: PI.
• 2018-2023: EP/R025398/1 Computational microscopy in Cambridge Advanced Imaging Centre, EPSRC fellowship, £450,498, role: PI.

Selected recent publications

Velazquez-Sanchez, C., Muresan, L., Marti-Prats, L. and Belin, D. (2023) 'The development of compulsive coping behaviour is associated with a downregulation of Arc in a Locus Coeruleus neuronal ensemble', Neuropsychopharmacology, 48(4).

Ball, M. L., Koestler, S. A., Muresan, L., Rehman, S. A., O’Holleran, K. and White, R. (2023) 'The anatomy of transcriptionally active chromatin loops in Drosophila primary spermatocytes using super-resolution microscopy', PLoS Genetics, 19(3).

Toader, B., Boulanger, J., Korolev, Y., Lenz, M. O., Manton, J., Schönlieb, C.-B. and Mureşan, L. (2022) 'Image reconstruction in light-sheet microscopy: spatially varying deconvolution and mixed noise', Journal of mathematical imaging and vision, 64(9).

Thomson, L., Muresan, L. and Steventon, B. (2021) 'The zebrafish presomitic mesoderm elongates through compaction-extension', Cells & development, 168.

Sims, R. R; Rehman, S. A., Lenz, M. O., Benaissa, S. I., Bruggeman, E., Clark, A., Sanders, E. W., Ponjavic, A., Muresan, L. and Lee, S. F. (2020) 'Single molecule light field microscopy', Optica, 7(9).

Hwang, M.‐S., Boulanger, J., Howe, J. D., Albecka, A., Pasche, M., Mureşan, L. and Modis, Y. (2019) 'MAVS polymers smaller than 80 nm induce mitochondrial membrane remodeling and interferon signaling', The FEBS journal, 286(8).

Turner-Bridger, B., Jakobs, M., Muresan, L., Wong, H. H.-W., Franze, K., Harris, W. A. and Holt, C. E. (2018) 'Single-molecule analysis of endogenous β-actin mRNA trafficking reveals a mechanism for compartmentalized mRNA localization in axons', Proceedings of the National Academy of Sciences, 115(41).

Gomez-Lamarca, M. J., Falo-Sanjuan, J., Stojnic, R., Rehman, S. A., Muresan, L., Jones, M. L., Pillidge, Z., Cerda-Moya, G., Yuan, Z. and Baloul, S. (2018) 'Activation of the Notch signaling pathway in vivo elicits changes in CSL nuclear dynamics', Developmental cell, 44(5).

Attardi, A., Fulton, T., Florescu, M., Shah, G., Muresan, L., Lenz, M. O., Lancaster, C., Huisken, J., van Oudenaarden, A. and Steventon, B. (2018) 'Neuromesodermal progenitors are a conserved source of spinal cord with divergent growth dynamics', Development, 145(21).

Urbano, J. M., Naylor, H. W., Scarpa, E., Muresan, L. and Sanson, B. (2018) 'Suppression of epithelial folding at actomyosin-enriched compartment boundaries downstream of Wingless signalling in Drosophila', Development, 145(8).

McColl, J., Mok, G. F., Lippert, A. H., Ponjavic, A., Muresan, L. and Münsterberg, A. (2018) '4D imaging reveals stage dependent random and directed cell motion during somite morphogenesis', Scientific Reports, 8(1).

Eldred, M. K., Charlton-Perkins, M., Muresan, L. and Harris, W. A. (2017) 'Self-organising aggregates of zebrafish retinal cells for investigating mechanisms of neural lamination', Development, 144(6).

Khalaf-Nazzal, R., Stouffer, M. A., Olaso, R., Muresan, L., Roumegous, A., Lavilla, V., Carpentier, W., Moutkine, I., Dumont, S. and Albaud, B. (2017) 'Early born neurons are abnormally positioned in the doublecortin knockout hippocampus', Human molecular genetics, 26(1).

Broadhead, M. J., Horrocks, M. H., Zhu, F., Muresan, L., Benavides-Piccione, R., DeFelipe, J., Fricker, D., Kopanitsa, M. V., Duncan, R. R. and Klenerman, D. (2016) 'PSD95 nanoclusters are postsynaptic building blocks in hippocampus circuits', Scientific reports, 6(1).

Davis, F. M., Lloyd-Lewis, B., Harris, O. B., Kozar, S., Winton, D. J., Muresan, L. and Watson, C. J. (2016) 'Single-cell lineage tracing in the mammary gland reveals stochastic clonal dispersion of stem/progenitor cell progeny', Nature communications, 7(1).

Wan, Y., Almeida, A. D., Rulands, S., Chalour, N., Muresan, L., Wu, Y., Simons, B. D., He, J. and Harris, W. A. (2016) 'The ciliary marginal zone of the zebrafish retina: clonal and time-lapse analysis of a continuously growing tissue', Development, 143(7).

Galli, E., Poidevin, M., Le Bars, R., Desfontaines, J.-M., Muresan, L., Paly, E., Yamaichi, Y., Barre, F.-X. (2016) 'Cell division licensing in the multi-chromosomal Vibrio cholerae bacterium', Nature microbiology, 1(9).

Lye, C. M., Blanchard, G. B., Naylor, H. W., Muresan, L., Huisken, J., Adams, R. J. and Sanson, B. (2015) 'Mechanical coupling between endoderm invagination and axis extension in Drosophila', PLoS biology, 13(11).

Chmielewski, A. K., Kyrsting, A., Mahou, P., Wayland, M. T., Muresan, L., Evers, J. F. and Kaminski, C. F. (2015) 'Fast imaging of live organisms with sculpted light sheets', Scientific reports, 5(1).

David, A., Demarre, G., Muresan, L., Paly, E., Barre, F.-X. and Possoz, C. (2014) 'The two Cis-acting sites, parS1 and oriC1, contribute to the longitudinal organisation of Vibrio cholerae chromosome I', PLoS genetics, 10(7).

Demarre, G., Galli, E., Muresan, L., Paly, E., David, A., Possoz, C. and Barre, F.-X. (2014) 'Differential management of the replication terminus regions of the two Vibrio cholerae chromosomes during cell division', PLoS genetics, 10(9).

Sams, M., Silye, R., Göhring, J., Muresan, L., Schilcher, K. and Jacak, J. (2014) 'Spatial cluster analysis of nanoscopically mapped serotonin receptors for classification of fixed brain tissue, Journal of biomedical optics', 19(1).

Cisse, I. I., Izeddin, I., Causse, S. Z., Boudarene, L., Senecal, A., Muresan, L., Dugast-Darzacq, C., Hajj, B., Dahan, M. and Darzacq, X. (2013) 'Real-time dynamics of RNA polymerase II clustering in live human cells', Science, 341, 6146.

Jacak, J., Schnidar, H., Muresan, L., Regl, G., Frischauf, A., Aberger, F., Schütz, G. J. and Hesse, J. (2013) 'Expression analysis of multiple myeloma CD138 negative progenitor cells using single molecule microarray readout', Journal of biotechnology, 164(4).

Boulanger, J., Muresan, L. and Tiemann-Boege, I. (2012) 'Massively parallel haplotyping on microscopic beads for the high-throughput phase analysis of single molecules', PLoS One, 7(4).

Muresan, L., Jacak, J., Klement, E. P., Hesse, J. and Schutz, G. J. (2010) 'Microarray analysis at single-molecule resolution', IEEE transactions on nanobioscience, 9(1).