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Dr Jufen Zhang

Associate Professor

Medical Technology Research Centre

Faculty of Health, Medicine and Social Care
School of Medicine
Areas of Expertise:
Medical statistics
Research Supervision:

Dr Zhang is a medical statistician. She is interested in clinical trials research and application of statistical methods to analyse clinical data.

[email protected]


Dr Jufen Zhang received her PhD from the University of Exeter. Before joining Anglia Ruskin University she worked as a Statistical Analyst at Hull York Medical School, University of Hull. She has provided statistical support to clinicians, researchers, and researcher students and has worked on a variety of clinical trials and observational studies.

Research interests

  • Statistical methodology
  • Applied statistics
  • Epidemiology
  • Experimental design

Areas of research supervision

  • Statistics in medical research
  • Epidemiology


  • PhD in Statistical Computing
  • MSc in Applied Statistics
  • BSc in Mathematics
  • Chartered Statistician, Royal Statistical Society

Memberships, editorial boards

  • Member of the Royal Statistical Society
  • Member of the International Society for Clinical Biostatistics
  • Editorial Board member of Developmental Medicine and Child Neurology as a statistical adviser
  • Reviewer for journals and grant proposals

Selected recent publications

S Sze, P Pellicori, J Zhang, J Weston, I B Squire, A L Clark. Effect of frailty on treatment, hospitalisation and death in patients with chronic heart failure. Clinical Research in Cardiology. 2021 Jan 5. doi: 10.1007/s00392-020-01792-w.

Ian Hanning, Pierpaolo Pellicori, Jufen Zhang, Sunil Bhandari, Andrew Clark, Parin Shah. The Effect of Digoxin on Renal Function in Patients with Heart Failure. Research Square. BMC Nephrology, 2021. DOI: 10.21203/rs.3.rs-140052/v1

Machado BHB, Frame J, Zhang J, Najlah M. Comparative Study on the Outcome of Periorbital Wrinkles Treated with Laser-Assisted Delivery of Vitamin C or Vitamin C Plus Growth Factors: A Randomized, Double-blind, Clinical Trial. Aesthetic Plast Surg. doi: 10.1007/s00266-020-02035-z. Published: 05 January 2021.

Philip Stather, Carroll Petty, Helen Langthorne, Emma Rayner, Jufen Zhang, Karen Hayden, Adam Howard. A randomised controlled clinical trial comparing the effectiveness of bandaging compared to the JuxtaCuresTM device in the management of people with venous ulceration: Feasibility Study. Phlebology. 2021 Jan 12; doi: 10.1177/0268355520988226.

Jufen Zhang, Karen Hayden, Ruth Jackson, Rudolph Schutte. Association of red and processed meat consumption with cardiovascular morbidity and mortality in participants with and without obesity: A prospective cohort study. Clinical Nutrition. 2020 Dec 29;S0261-5614(20)30705-6. doi: 10.1016/j.clnu.2020.12.030.

Shahina Pardhan, Megan Vaughan, Jufen Zhang, Lee Smith, Havovi Chichger. Sore eyes as the most significant symptom experienced by people with COVID-19. A comparison between pre-and post-COVID-19 states. BMJ Open Ophthalmology. 2020; 5(1): e000632.

Jufen Zhang, Pierpaolo Pellicori, Rudolph Schutte, John G. Cleland. The association between blood groups and COVID-19 infection: a study from the UK Biobank. The Journal of Internal Medicine. 2020 Dec 11. doi: 10.1111/joim.13226.

Artemis Matsou, Rathin Pujari, Hammad Sarwar, Mrinal Rana, James Myerscough, Susan M Thomson, Girinath Nandakumar, Jufen Zhang, Madhavan S Rajan. Microthin Descemet Stripping Automated Endothelial Keratoplasty Versus Descemet Membrane Endothelial Keratoplasty: A Randomized Clinical Trial. Cornea. 2020 Nov 3. doi: 10.1097/ICO.0000000000002601.

Jufen Zhang, Karen Hayden, Ruth Jackson, Rudolph Schutte. Associations of weight changes with all-cause, cancer and cardiovascular mortality: A prospective cohort study. Public Health in Practice. 2:100065. DOI: 10.1016/j.puhip.2020.100065.

Cleland JG, Zhang J, Pellicori P, Dicken B, Dierckx R, Shoaib A, Wong K, Rigby A, Goode K, Clark AL. Prevalence and Outcomes of Anemia and Hematinic Deficiencies in Patients with Chronic Heart Failure. JAMA Cardiol. 2016 Aug 1;1(5):539-47

Maria Quintana, Peter Anderberg, Johan Sanmartin Berglund, Joakim Frögren, Neus Cano, Selim Cellek, Jufen Zhang, Maite Garolera. Feasibility-usability study of a tablet app adapted specifically for persons with cognitive impairment – SMART4MD (Support Monitoring and Reminder Technology for Mild Dementia). Int J Environ Res Public Health. 2020 Sep 18;17(18):6816

Shirley Sze, Pierpaolo Pellicori, Jufen Zhang, Joan Weston, Andrew L Clark. The impact of malnutrition on short-term morbidity and mortality in ambulatory patients with heart failure. The American Journal of Clinical Nutrition. 2020 Nov 24;nqaa311. doi: 10.1093/ajcn/nqaa311.

Alexander Street, Jufen Zhang, Susan Pethers, Lydia Wiffen, Katie Bond, and Helen Palmer. Neurologic music therapy in multidisciplinary acute stroke rehabilitation: Could it be feasible and helpful? TOPICS IN STROKE REHABILITATION. https://doi.org/10.1080/10749357.2020.1729585

Syed Ghufran Khalid, Liu Haipeng, Tahir Zia, Jufen Zhang, Fei Chen, Dingchang Zheng. Cuffless Blood Pressure Estimation Using Single Channel Photoplethysmography: A Two Step Method. IEEE Access. Accepted. 2020. DOI: 10.1109/ACCESS.2020.2981903

Rudolph Schutte, Maria Papageorgiou, Mohammad Najlah, Hugo W. Huisman, Cristian Ricci. Jufen Zhang, Nicky Milner, Aletta E. Schutte. Drink types unmask the health risks associated with alcohol intake - Prospective evidence from the general population. Clinical Nutrition. 2020. ISSN 1532-1983

Pierpaolo Pellicori, Jufen Zhang, Joe Cuthbert, Alessia Urbinati, Parin Shah, Syed Kazmi, Andrew L Clark, John GF Cleland. High sensitivity C-Reactive Protein in Chronic Heart Failure. Patient Characteristics, Phenotypes and Mode of Death. Cardiovascular Research, Volume 116, Issue 1, 1 January 2020, Pages 91–100.

Hilary Bungay, Suzanne Hughes, Clare Jacobs, Jufen Zhang. Dance for Health: The impact of creative dance sessions on older people in an acute hospital setting. Arts Health. 2020 Feb 6;1-13. doi: 10.1080/17533015.2020.1725072

Jufen Zhang, Aine Begley, Ruth Jackson, Michael Harrison, Pierpaolo Pellicori, Andrew L Clark, John GF Cleland. Body mass index and all-cause mortality in heart failure patients with normal and reduced ventricular ejection fraction - a dose-response meta-analysis. Clinical Research in Cardiology. Clin Res Cardiol. 2019 Feb;108(2):119-132.

Pierpaolo Pellicori, Alessia Urbinati, Kuldeep Kaur, Jufen Zhang, Parin Shah, Syed Kazmi, Alessandro Capucci, John GF Cleland, Andrew L. Clark. Prevalence and Incidence of Atrial Fibrillation in Ambulatory Patients with Heart Failure. The American Journal of Cardiology. Volume 124, Issue 10, 15 November 2019, Pages 1554-1560.

Shirley Sze, Pierpaolo Pellicori, Jufen Zhang, Andrew Clark. Identification of Frailty in Chronic Heart Failure. JACC Heart Failure. 2019 Feb 4. S2213-1779(18)30912-0.

Pierpaolo Pellicori, Parin Shah, Joe Cuthbert, Alessia Urbinati, Jufen Zhang, Anna Kallvikbacka-Bennett BA, Andrew L Clark, John GF Cleland. Prevalence, pattern and clinical relevance of ultrasound indices of congestion in out-patients with heart failure. European Journal of Heart Failure. 2019 Jul;21(7):904-916. doi: 10.1002/ejhf.1383.

Parin Shah, Pierpaolo Pellicori, Anna Kallvikbacka-Bennett, Jufen Zhang, Daniel Pan, Andrew L Clark. Warm water immersion in patients with chronic heart failure: A pilot study. Clinical Research in Cardiology. 2019 May;108(5):468-476.

Shirley Sze, Pierpaolo Pellicori, Jufen Zhang, Andrew Clark. Malnutrition, congestion and mortality in ambulatory patients with heart failure. Heart. 2018. pii: heartjnl-2018-313312. doi: 10.1136/.

S. Ghufran Khalid, Jufen Zhang, Fei Chen, Dingchang Zheng. Blood Pressure Estimation using Photoplethysmography only: Comparison between Different Machine Learning Approaches. Journal of Healthcare Engineering. Volume 2018, Article ID 1548647.

J Ward, G Phillips, I Radotra, S Smiles, P Dziewulski, J Zhang, N Martin. Frailty: an independent predictor of burns mortality following in patient admission. Burns. 2018 Dec;44(8):1895-1902.

J. Zhang, P. Pellicori, D. Pan, R. Dierckx, AL. Clark, JGF. Cleland. Dynamic Risk Stratification using Serial Measurements of Plasma Concentrations of Natriuretic Peptides in Patients with Heart Failure. International Journal of Cardiology, 2018 Oct 15;269:196-200. doi: 10.1016

Pellicori, P., Urbinati, A., Zhang, J., Joseph,A.C., Costanzo, P., Lukaschuk, E., Capucci, A. and Cleland, J.G.F. Clinical and prognostic relationships of pulmonary artery to aorta diameter ratio in patients with heart failure. A cardiac magnetic resonance imaging study. Clin Cardiol. 2018 Jan;41(1):20-27 Jan;41(1):20-27. doi: 10.1002/clc.22840.

Shah R. Mohdnazri, Grigoris V. Karamasis, Firas Al-Janabi, Christopher M. Cook, James Hampton-Till, Jufen Zhang, Rasha Al-Lamee, Jason N. Dungu, Swamy Gedela , Kare H. Tang, Paul A. Kelly, Justin E. Davies, John R. Davies, Thomas R. Keeble. The Impact of Coronary Chronic Total Occlusion (CTO) Percutaneous Coronary Intervention (PCI) Upon Donor Vessel Fractional Flow Reserve (FFR) and Instantaneous Wave-Free Ratio (iFR): Implications for Physiology-Guided PCI in Patients With CTO study. Catheter Cardiovasc Interv. 2018 Sep 1;92(3):E139-E148.

Theodora Nikolaidou, Pierpaolo Pellicori, Jufen Zhang, Syed Kazmi, Kevin M Goode, John G Cleland, Andrew L Clark. Prevalence, predictors and prognostic implications of PR interval prolongation in patients with heart failure. Clin Res Cardiol. 2018 Feb;107(2):108-11. doi: 10.1007/s00392-017-1162-6.

Sze S, Zhang J, Pellicori P, Morgan D, Hoye A, Clark AL. Prognostic value of simple frailty and malnutrition screening tools in patients with acute heart failure due to left ventricular systolic dysfunction. Clin Res Cardiol. 2017 Jul;106(7):533-541.

Pierpaolo Pellicori, Andrew L. Clark, Anna Kallvikbacka-Bennett, Jufen Zhang, Alessia Urbinati, Luca Monzo, Riet Dierckx, Stefan D Anker, John GF Cleland. Non-Invasive measurement of Right Atrial Pressure by Near-Infrared Spectroscopy: Preliminary Experience. A Report from the SICA-HF Study. European Journal of Heart Failure. 2017, 19(7), pp. 883-892

Jufen Zhang, Kenneth Y-K. Wong, Andrew L. Clark, John G.F. Cleland. Exploring the relation between changes in NT-proBNP and renal function in patients with suspected heart failure using structural equation modelling. International Journal of Cardiology. 233 (2017) 67–72.

Pellicori P, Urbinati A, Shah P, MacNamara A, Kazmi S, Dierckx R, Zhang J, Cleland JG, Clark AL. What proportion of patients with chronic heart failure are eligible for sacubitril–valsartan? Eur J Heart Fail. 2017 Jun;19(6):768-778.

Jufen Zhang, Riet Dierckx, Kevin Mohee, Andrew L. Clark, John G. Cleland. Xanthine Oxidase Inhibition for the Treatment of Cardiovascular Disease: An Updated Systematic Review and Meta-Analysis. ESC Heart Failure 2017; 4: 40–45.

Pellicori P, Cleland JG, Zhang J, Bennett A, Urbinati A, Shah P, Kazmi S, Clark AL. Cardiac Dysfunction, Congestion and Loop Diuretics: Their Relationship to Prognosis in Heart Failure. Cardiovascular Drugs and Therapy, Cardiovasc Drugs Ther. 2016 Dec;30(6):599-609.

Cleland JG, Zhang J, Pellicori P, Dicken B, Dierckx R, Shoaib A, Wong K, Rigby A, Goode K, Clark AL. Prevalence and Outcomes of Anemia and Hematinic Deficiencies in Patients with Chronic Heart Failure. JAMA Cardiol. 2016 Aug 1;1(5):539-47

Jufen Zhang, James Hobkirk, Sean Carroll, Pierpaolo Pellicori, Andrew L. Clark, John G.F. Cleland. Exploring quality of life in patients with and without heart failure. International Journal of Cardiology 202 (2016) 676–684.

Pierpaolo Pellicori, Anil C. Joseph, Jufen Zhang, Elena Lukaschuk, Nasser Sherwi, Christos V. Bourantas, Huan Loh, Andrew L. Clark, John GF Cleland. The Relationship of QRS Morphology with Cardiac Structure and Function in Patients with Heart Failure. Clin Res Cardiol. 2015 Nov;104(11):935-45

Farag Mohamed, Mabote Thato, Shoaib Ahmad, Zhang Jufen, Nabhan Ashraf F, Clark Andrew L, Cleland John G. Hydralazine and Nitrates Alone or Combined for the Management of Chronic Heart Failure: A Systematic Review. International Journal of Cardiology (2015), 196, 61-69.

Pierpaolo Pellicori, Jufen Zhang, Elena Lukaschuk, Anil C Joseph, Christos V Bourantas, Huan Loh, Thanjavur Bragadeesh, Andrew L Clark, John GF Cleland. Left Atrial Function Measured by Cardiac Magnetic Resonance Imaging in Patients with Heart Failure: Clinical Associations and Prognostic Value. European Heart Journal (2015) 36, 733–743

Dierckx R, Cleland JGF, Pellicori P, Zhang J, Clark AL. "If home telemonitoring reduces mortality in heart failure, is this just due to better guideline-based treatment?" Journal of Telemedicine and Telecare, 2015, 0(0) 10-9.

Pierluigi Costanzo, MD, MSc; John G.F. Cleland, MD; Pierpaolo Pellicori, MD; Andrew L. Clark, MD; David Hepburn, MD; Eric S. Kilpatrick, MD; Pasquale Perrone-Filardi, MD, PhD; Jufen Zhang, MSc, PhD; and Stephen L. Atkin, MD, PhD. The Obesity Paradox in Type 2 Diabetes Mellitus: Relationship of Body Mass Index to Prognosis: A Cohort Study. Ann Intern Med. 2015;162(9):610-618.

Pierpaolo Pellicori, Anna Kallvikbacka-Bennett, Riet Dierckx, Jufen Zhang, Paola Putzu, Joe Cuthbert, Vennela Boyalla, Ahmed Shoaib, Andrew L Clark, John GF Cleland. Prognostic Significance of Ultrasound-Assessed Jugular Vein Distensibility in Heart Failure, Heart 2015 Jul;101(14):1149-58

Nasser Sherwi, Kenneth Wong, Jufen Zhang, Pierpaolo Pellicori, Olga Khaleva, Christos Bourantas, Azam Torabi, Andrew Clark and John G Cleland. The Prevalence of Extra-cranial Carotid Artery Disease in Chronic Heart Failure. Cardiology and Angiology: An International Journal. 3(1): 17-26, 2015

Damien Cullington, Kevin M. Goode, Jufen Zhang, John G.F. Cleland, Andrew L. Clark. Is Heart Rate Important for Patients With Heart Failure in Atrial Fibrillation? JACC Heart Failure. 2014; 2(3):213-220

J Zhang, R Dierckx, JG Cleland. “Xanthine Oxidase Inhibition for the Treatment of Cardiovascular Disease: A Systematic Review and Meta-Analysis”. Cardiovascular Therapeutics. April 2014, volume 32, issue 2, pages 57–58,

Pellicori P, Kallvikbacka-Bennett A, Zhang J, Khaleva O, Andrew L. Clark, John G. F. Cleland, J, Warden. Revisiting a classical clinical sign: jugular venous ultrasound. Int J Cardiol. 2014 Jan 1; 170(3):364-70

Pellicori P, Kallvikbacka-Bennett A, Khaleva O, Carubelli V, Costanzo P, Castiello T, Wong K, Zhang J, Cleland JG, Clark AL. Global longitudinal strain in patients with suspected heart failure and a normal ejection fraction: does it improve diagnosis and risk stratification? Int J Cardiovasc Imaging. 2014 Jan;30(1):69-79.

J. Zhang, K.M. Goode, A.S. Rigby, Balk AH, J.G.F. Cleland, Identifying patients at risk of death or hospitalisation due to worsening heart failure using decision tree analysis: Evidence from Trans-European Network-Home-Care Management System (TEN-HMS) Study. International Journal of Cardiology (2013) 163(2): 149-56

Pierpaolo Pellicori, Valentina Carubelli, Jufen Zhang, Teresa Castiell, Nasser Sherwi, Andrew L. Clark, John G. F. Cleland, IVC Diameter in Patients With Chronic Heart Failure. Relationships and Prognostic Significance. JACC: Cardiovascular Imaging, 2013 Jan; 6(1):16-28 – 2012 Young Author Achievement Award for JACC Cardiovascular Imaging.

Thibaud Damy, Anna Kallvikbacka-Bennett, Jufen Zhang, Kevin Goode, Laszlo Buga, James Hobkirk, Ashraf Yassin, Jean-Luc Dubois-Rande, Luc Hittinger, John G. F. Cleland, Andrew L. Clark, Does the physical examination still have a role in patients with suspected heart failure? European Journal of Heart Failure (2011), volume 13, 1340-1348.

Zhang J, Goode KM, Cuddihy P, Cleland JG, Predicting hospitalisation due to worsening heart failure using daily weight measurement: An analysis of the Trans-European Network-Home-Care Management System (TEM-HMS) Study. European Journal of Heart Failure (2009) 11, 420-427.

Alan S Rigby, Jufen Zhang and Kevin M Goode, Statistical Methods in Epidemiology. IX. Survival (Failure-time) Models. Disability and Rehabilitation, 2009; 1–6

Book chapters

John G.F. Cleland, Azam Torabi, Jufen Zhang, and Raj K. Chelliah, Chapter: Medical therapy for chronic heart failure, 43: Antithrombotic agents, Oxford Textbook of Heart Failure. 978-0-19-957772-9 | Hardback | July 2011

Recent presentations and conferences

The factors associated with heart failure hospitalization rates in heart failure patients with normal and reduced left ventricular ejection fraction. ESC Heart Failure congress 2016

Predicting Survival in Patients with Heart Failure Based on Variables Used in the MAGGIC model. The European Society of Cardiology (ESC) Heart Failure 2015

Dynamic prediction using joint models in patients with suspected heart failure. Statisticians in the Pharmaceutical Industry 2014 Conference

Factors associated with quality of life in patients with suspected heart failure. The European Society of Cardiology (ESC) Heart Failure 2013

Mortality risk stratification in chronic heart failure patients: an analysis of the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA). The ESC Congress 2012